SBGneuro
MR imaging analysis for clinical trials

Imaging endpoints you can trust, from protocol to publication

SBGneuro provides expertise in the acquisition, quality control, analysis and interpretation of MRI as an outcome measure in clinical trials, from the people who build the field's standard analysis tools.

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ISO 9001 Quality Management certification mark of the British Assessment Bureau, UKAS accredited
ISO 9001:2015 certifiedQuality management system
Lead developers of FSLUsed in 2,500+ institutions
500+ papers · 200k+ citationsFrom our founding scientists
Est. 2012 · Oxford, UKServing sponsors and CROs worldwide
Why SBGneuro

We wrote the methods. Now we apply them to your trial.

Method authors, not just users

Our founders created many of the techniques behind modern MRI analysis, including FSL, ICA-based resting-state analysis and dual regression. You get that depth on every study.

Built for regulated work

An ISO 9001-certified quality system, pre-specified analysis plans, QC before analysis and deliverables to CDISC SDTM, so imaging data is ready for your submission.

Maximum security, minimum overhead

We work from de-identified data via encrypted transfer to dedicated servers, with an extensive in-house analyst team that integrates with your CRO rather than adding layers.

Services

Support across the whole trial lifecycle

All services →
01 Pre-trial consultancy Study design, MR physics consultancy, protocol design and acquisition optimisation. 02 Imaging study support Site qualification, cross-site harmonisation, ongoing site QC and data transfer specifications. 03 Data analysis Outcome measures, statistical analysis plans, quality control, interim and final analysis. 04 Interpretation Turning imaging biomarkers into a clear clinical account, plus publication support.
Modalities

Every major MR biomarker, under one roof

We extract a large repertoire of outcome measures, each a valid and distinct marker of brain structure, activity or connectivity, and integrate them with clinical and behavioural data.

Structural MRISegmentation, volumetry and longitudinal atrophy
Lesion analysisAutomated T2-FLAIR white-matter lesions
Resting-state fMRINetwork maps, amplitude and functional connectivity
Task fMRIReady-to-deploy paradigms, analysed from subject to group level
Diffusion MRIMicrostructure, tractography and structural connectivity
Perfusion (ASL)Absolute and relative cerebral blood flow
Sites and tasks

From scanner set-up to the last task trial

Site support and task battery →
Study in a BoxA lockable kit for stimulus presentation and automatic, encrypted data upload at every site.
Imaging site supportHardware and software support, operator training, site qualification and ongoing QA.
Compliant data transferGDPR- and HIPAA-compliant solutions for moving imaging and task data securely.
Ready-to-deploy task fMRIGo/No-Go, MID, SID, N-Back, SST, delay discounting, food reward and more, plus custom tasks.
How we work

A streamlined, secure pipeline

  1. 1Secure receiptDe-identified data from the CRO via encrypted transfer.
  2. 2Quality controlEvery scan checked first, billed separately from analysis.
  3. 3Tailored processingA pipeline agreed with your trial team and CRO.
  4. 4AnalysisPre-specified structural and functional outcome measures.
  5. 5DeliveryResults to agreed specifications, with interpretation.
Our approach to quality and security →

Proven at the scale of the world's largest imaging studies

Our track record →
UK BiobankBrain imaging of 100,000 participants. Stephen Smith leads the brain imaging component.
Human Connectome ProjectMajor analysis components contributed by Beckmann and Smith.
PRISM 1 & 2 / TRANSFORMThree large European IMI and IHI projects on transdiagnostic biomarkers, with SBGneuro as partner.

Planning a trial with an imaging endpoint?

Talk to us early. The right protocol and outcome measures are easiest to set before the first scan.

Discuss your study